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The Sign of the Four, or The Sign of Four, is a detective novel written by Sir Arthur Conan Doyle, the second novel featuring Sherlock Holmes and his assistant Dr. John Watson. The novel was first published in 1890 and is set in London in the late 19th century.

The plot revolves around a stolen treasure from India and a complex web of murder, deceit, and betrayal. Holmes and Watson are hired by a young woman named Mary Morstan, who receives a mysterious note promising the return of her missing father. The investigation leads them to an ex-prisoner named Jonathan Small and the mysterious Thaddeus Sholto, who holds the key to the treasure's location. The story is set against the backdrop of colonialism and British rule in India.

The Sign of the Four has been adapted into several films, television shows, and stage productions, and is considered a classic of the detective genre.